Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is acleavablePEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

373.78

C₁₃H₂₄ClNO₉

1416771-72-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.