Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide basedcereblonligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series ofPROTACs, such as SJF620 (HY-133137). SJF620 is a potentPROTACBTK degrader with a DC₅₀of 7.9 nM^[1].

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620 is a potent PROTAC BTK degrader consisting of the BTK inhibitor conjugated to Lenalidomide by a linker^[1].

502.30

C₁₉H₂₃IN₂O₆

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