Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the Pomalidomide basedcereblonligand and 3-unit PEG linker used inPROTACtechnology^[1].

Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) can be used to synthesize BI-3663. BI-3663 (cereblon-based) degrades focal adhesion tyrosine kinase (PTK2) with a median DC₅₀of 30 nM to >80% across a panel of 11 human hepatocellular carcinoma (HCC) cell lines^[1].

476.48

C₂₂H₂₈N₄O₈

2328070-52-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.