(S,R,S)-AHPC-PEG2-C4-Cl

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1835705-57-1

包装与价格：

包装	价格(元)
100mg	电议
500mg	电议
1 g	电议
2 g	电议
5 g	电议
10 g	电议

产品名称

VH032-PEG2-C4-Cl
VHL Ligand-Linker Conjugates 7
E3 ligase Ligand-Linker Conjugates 10

产品介绍

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) 由 E3 配体与 13 个原子相连的复合分子，连接子的接头为 Halogen 基团。(S,R,S)-AHPC-PEG2-C4-Cl 包含基于 (S,R,S)-AHPC 的 VHL 配体和 alkyl/ether linker。(S,R,S)-AHPC-PEG2-C4-Cl 能够诱导 GFP-HaloTag7 降解。

生物活性

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays^[1].

IC₅₀& Target^[1]

VHL

体外研究
(In Vitro)

(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand^[1]. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase^[2].

分子量

651.26

性状

Oil

Formula

C₃₂H₄₇ClN₄O₆S

CAS 号

1835705-57-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL(76.77 mM)

Ethanol : 50 mg/mL(76.77 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5355 mL	7.6774 mL	15.3548 mL
5 mM	0.3071 mL	1.5355 mL	3.0710 mL
10 mM	0.1535 mL	0.7677 mL	1.5355 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。