GSK2292767 is a potent and selective inhibitor ofPI3Kδ, with apIC₅₀of 10.1. GSK2292767 showing greater than 500-fold selective over the otherPI3Kisoforms. GSK2292767 can be used for the research of respiratory disease^[1].

GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F< 2%) in a rat PK study^[1].
GSK2292767 (0.01-1 μM) has no effect on QT interval, T_p-e, or QRS and no significant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay^[1].
GSK2292767 protects against eosinophil recruitment with an ED₅₀of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven inflammation in the lungs of rats^[1].

512.58

C₂₄H₂₈N₆O₅S

1254036-66-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.