PI3K-IN-33

立即咨询

PI3K-IN-33

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2458163-92-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI3K-IN-33 (Compound 6e) 是一种高选择性的PI3K抑制剂，PI3K-α，PI3K-β 和 PI3K-δ 的IC₅₀值分别为 11.73、6.09 和 11.18 μM。PI3K-IN-33 阻滞细胞周期于 G2/M 期并诱导细胞凋亡。PI3K-IN-33 可用于白血病研究。

生物活性

PI3K-IN-33 (Compound 6e) is a highly selectivePI3Kinhibitor withIC₅₀values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and inducesapoptosis. PI3K-IN-33 can be used in leukemia research^[1].

IC₅₀& Target^[1]

PI3Kα

11.73 μM (IC₅₀)

PI3Kβ

6.09 μM (IC₅₀)

PI3Kδ

11.18 μM (IC₅₀)

体外研究
(In Vitro)

PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro^[1].
PI3K-IN-33 (Compound 6e) induces cell cycle arrest toward the G2-M phase (30.3%) and leads to DNA synthesis and apoptosis^[1].
PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) results in apoptotic with 12.13% of cells in the early and latest age^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	Leukemia SR cell lines.
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Antiproliferative activity with values of 0.76 μM.

分子量

493.36

Formula

C₂₃H₂₁BrN₆O₂

CAS 号

2458163-92-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.