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Propargyl-PEG3-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG3-acid图片
CAS NO:1347760-82-0
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Propargyl-PEG3-acid是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker,同时也是基于PEG的PROTAC linker,可用于合成6-OHDA-PEG3-yne。6-OHDA-PEG3-yne 包含6-OHDA 和Propargyl-PEG3-acid。
Cas No.1347760-82-0
别名丙炔基-二聚乙二醇-羧酸
分子式C10H16O5
分子量216.23
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377. [2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.