PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with anIC₅₀of 7 nM forPI3Kαin a cell assay, andK_is of 10.6 nM and 12.5 nM formTORandPI3Kαin a cell free assay , respectively.

PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties^[1].

PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate V_dss, T_1/2of 0.9 h, and good oral bioavailability^[1].

310.35

C₁₆H₁₈N₆O

1013098-90-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.