AZD3147 is a potent, orally active, selective dual inhibitor ofmTORC1andmTORC2with anIC₅₀value of 1.5 nM. AZD3147 also has a selective effect onPI3K^[1].

AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells^[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC₅₀values of 0.88 nM and 662.4 nM, respectively^[3].

The pharmacokinetic parameters of AZD3147^[1].

517.66

C₂₄H₃₁N₅O₄S₂

1101810-02-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.