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CpdA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CpdA图片
CAS NO:1415834-63-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 388.8
Formula C20H15ClF2N2O2
CAS No. 1415834-63-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:10 mM
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES O=C(NC1=NC=CC(OCC2=CC=C(Cl)C=C2)=C1)CC3=C(F)C=CC=C3F
Synonyms CPDA; N-[4-(4-chlorobenzyloxy)pyridin-2-yl]-2-(2,6-difluorophenyl)- acetamide
实验参考方法
In Vitro

In vitro activity: CPDA [N-[4-(4-chlorobenzyloxy)pyridin-2-yl]-2-(2,6-difluorophenyl)- acetamide] is a novel potent inhibitor of SHIP2 [SH2-containing 5'-inositol phosphatase 2] that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes. CPDA was identified using in-silico ligand-based drug design (LBDD) in an attempt to identify inhibitors of SH2-containing 5'-inositol phosphatase 2 (SHIP2), which is implicated in insulin-resistant type 2 diabetes. Among the compounds synthesized, (CPDA, 4a) was identified as a potent SHIP2 inhibitor. CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice.


Kinase Assay: CPDA was found to enhance insulin signaling.


Cell Assay:

In Vivo CPDA greatly improves abnormal glucose metabolism in diabetic animals.
Animal model
Formulation & Dosage
References Eur J Med Chem. 2013 Apr;62:649-60.