TC-G 24

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TC-G 24

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1257256-44-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

TC-G 24 (Compound 24) 是一种有效的、选择性的糖原合成酶激酶 3β (GSK-3β) 抑制剂，IC₅₀值为 17.1 nM。TC-G 24 能透过血脑屏障 (BBB)，可以用于研究许多疾病，如 2 型糖尿病、中风、阿尔茨海默病和其他相关疾病。

生物活性

TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with anIC₅₀of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases^[1].

IC₅₀& Target

GSK-3β

17.1 nM (IC₅₀)

体外研究
(In Vitro)

TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β^[1].
TC-G 24 (1 μM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells^[2].

Western Blot Analysis^[2]

Cell Line:	293T cells
Concentration:	1 μM
Incubation Time:	4 h
Result:	Blocked the FBW7α-mediated degradation of TPP1

体内研究
(In Vivo)

TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB^[1].

Animal Model:	Six-week-old male C57BL/6N mice with weights averaging 22 g^[1]
Dosage:	1, 5, and 15 mg/kg
Administration:	Intraperitoneal injection, once
Result:	Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).

分子量

330.73

Formula

C₁₅H₁₁ClN₄O₃

CAS 号

1257256-44-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.