ZLWH-23

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ZLWH-23

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2765251-12-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ZLWH-23 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂(IC₅₀=0.27 μM)，具有抑制 GSK-3β 的特性 (IC₅₀=6.78 μM)。ZLWH-23 对 BChE (IC₅₀=20.82 μM) 上的乙酰胆碱酯酶和对多种激酶以及 GSK-3β 具有选择性。ZLWH-23 具有研究阿尔茨海默病的潜力。

生物活性

ZLWH-23 is a selectiveAChEinhibitor (IC₅₀=0.27 μM) withGSK-3βinhibitory property (IC₅₀=6.78 μM). ZLWH-23 possesses selectivity forAChEoverBChE(IC₅₀=20.82 μM) and forGSK-3βover multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease^[1].

IC₅₀& Target^[1]

GSK-3β

6.78 μM (IC₅₀)

AChE

0.27 μM (IC₅₀)

体外研究
(In Vitro)

ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines^[1].

体内研究
(In Vivo)

ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model^[1].

分子量

513.61

Formula

C₃₀H₃₂FN₅O₂

CAS 号

2765251-12-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.