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Uprosertib hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Uprosertib hydrochloride图片
CAS NO:1047635-80-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GSK2141795 (hydrochloride)
产品介绍
Uprosertib hydrochloride (GSK2141795 hydrochloride) 是一种有效的,选择性的Akt广谱抑制剂,抑制 Akt1/Akt2/Akt3 的活性,IC50值分别为 180/328/38 nM。
生物活性

Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selectivepan-Aktinhibitor withIC50values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

IC50& Target[1]

Akt1

180 nM (IC50)

Akt2

328 nM (IC50)

Akt3

38 nM (IC50)

CDK7

2100 nM (IC50)

ROCK1

1570 nM (IC50)

ROCK2

1850 nM (IC50)

体外研究
(In Vitro)

Uprosertib inhibits Akt1/2/3 with the Kdvalues of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding[1].

Clinical Trial
分子量

465.71

Formula

C18H17Cl3F2N4O2

CAS 号

1047635-80-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.