CCG-232601 (compound 8f) 是一种有效的口服活性 Rho/MRTF/SRF 转录途径抑制剂。
| Cas No. | 1922099-21-5 |
| Canonical SMILES | O=C(N1CC(F)(F)CC(C(NC2=CC=C(Cl)C=C2)=O)C1)C3=CC(C4=CC=NC=C4)=CC=C3 |
| 分子式 | C24H20ClF2N3O2 |
| 分子量 | 455.9 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway and a derivative of CCG-203971 . CCG-232601 inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay). It also reduces expression of α-smooth muscle actin (α-SMA) in TGF-β-stimulated human dermal fibroblasts to 31% of control when used at a concentration of 10 µM. CCG-232601 (50 mg/kg) inhibits increases in dermal thickness and hydroxyproline content in a mouse model of dermal fibrosis induced by bleomycin . |
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