您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > DDD85646
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DDD85646
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DDD85646图片
CAS NO:1215010-55-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
DDD85646 是一种有效的布氏锥虫 N-肉豆蔻酰转移酶抑制剂（TbNMT IC50=2 nm；hNMTIC50=4 nm）。
Cas No.1215010-55-1
别名IMP-366
化学名2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
Canonical SMILESClC1=CC(C2=CC=NC(N3CCNCC3)=C2)=CC(Cl)=C1S(NC4=C(C)N(C)N=C4C)(=O)=O
分子式C21H24Cl2N6O2S
分子量495.4
溶解度25mg/ml in DMSO & DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM.1 T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT.[1] It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).

Reference:
1. Frearson, J.A., Brand, S., McElroy, S.P., et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 464(7829), 728-732 (2010).