Isobavachalcone (Corylifolinin) is derived fromPsoralea corylifolia Linn.and is a potent inhibitor ofAktsignaling pathway, which inducesapoptosisin humancancercells (Inhibits OVCAR-8 cell growth with anIC₅₀value of 7.92 μM). Isobavachalcone also inducesReactive Oxyen Species (ROS)generation in OVCAR-8 cells and has exhibitcanceranti-promotive and anti-proliferative activity^[1].

IC50: 7.92 μM (OVCAR-8 cell)^[1]

Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively^[1].
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation^[1].
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway^[1].

Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing^[1].

324.37

Solid

C₂₀H₂₀O₄

20784-50-3

补骨脂乙素；补骨酯乙素；异补骨脂查耳酮；异补骨脂查尔酮

• Flavonoids
• Chalcones

• Phenols
• Polyphenols

• Plants
• Leguminosae
• Psoralea corylifoliaL.

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 11 mg/mL(33.91 mM;Need ultrasonic and warming)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。