Albendazole (SKF-62979) is an orally active and broad-spectrumparasiticidewith high effectiveness and low host toxicity, is used for the research of gastrointestinalparasitesin humans andanimals. Albendazole inducesapoptosisandautophagyincancercells. Albendazole also inhibitstubulinpolymerization andHIF-1α,VEGFexpression, has antioxidant activity, and inhibits the glycolytic process incancercells^{[1][2][3][4][5]}.

parasites, tubulin^[1][2].
HIF-1α, VEGF^[3].

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner^[1].
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle^[1].
Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner^[2].
Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells^[2].
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells^[3].

Albendazole (10 mg/kg; i.g.; once a day for 30 days) reducesEchinococcus granulosuscyst weights in mice^[4].
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo^[1].

265.33

Solid

C₁₂H₁₅N₃O₂S

54965-21-8

阿苯达唑；丙硫达唑；丙硫咪唑；抗蠕敏；扑尔虫；肠虫清

Room temperature in continental US; may vary elsewhere.

DMSO : 20 mg/mL(75.38 mM;Need ultrasonic)

H₂O : 0.67 mg/mL(2.53 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 10% DMSO    40%PEG300   5%Tween-80   45% saline

  Solubility: 2 mg/mL (7.54 mM); Suspended solution; Need ultrasonic

  此方案可获得 2 mg/mL (7.54 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

  以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

  将 0.9 g 氯化钠，完全溶解于 100 mL ddH2O 中，得到澄清透明的生理盐水溶液
• 2.

  请依序添加每种溶剂： 10% DMSO    90%corn oil

  Solubility: ≥ 2 mg/mL (7.54 mM); Clear solution

  此方案可获得 ≥ 2 mg/mL (7.54 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

  以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。