Tin-protoporphyrin IX (SnPPIX) is a potentHeme oxygenase-1 (HO-1)inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model^[1].

IC50: Heme oxygenase-1 (HO-1)^[1]

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM^[1].

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P< 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment^[1].

750.26

Solid

C₃₄H₃₂Cl₂N₄O₄Sn

14325-05-4

锡原卟啉IX

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

0.1 M NaOH : 14.29 mg/mL(19.05 mM;ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL(1.33 mM;Need ultrasonic and warming)

DMSO : 0.5 mg/mL(0.67 mM;Need ultrasonic and warming)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。