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L-152,804
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-152,804图片
CAS NO:6508-43-6
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
L-152,804 是一种具有口服活性的选择性神经肽 Y Y5 受体 (NPY5-R) 拮抗剂，对 hY5 的 Ki 值为 26 nM。
Cas No.6508-43-6
化学名(R)-2-(3,3-dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione
Canonical SMILESO=C(CC(C)(C)CC1=O)C1[C@H]2C3=C(CC(C)(C)CC3=O)OC4=CC=CC=C24
分子式C23H26O4
分子量366.46
溶解度<36.65mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].

L 152804 displays >300-fold selectivity over hY1, hY2, and hY4 receptors[1].

References:
[1]. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.
[2]. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.