| CAS NO: | 287194-38-1 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | DHMEQ racemate is aNF-κBinhibitor. DHMEQ racemate is less active than (-)-DHMEQ. | ||||||||||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1]. | ||||||||||||||||
| 体内研究 (In Vivo) | The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1]. | ||||||||||||||||
| 分子量 | 261.23 | ||||||||||||||||
| Formula | C13H11NO5 | ||||||||||||||||
| CAS 号 | 287194-38-1 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||||||||||
| 溶解性数据 | In Vitro: DMSO : ≥ 32 mg/mL(122.50 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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