Fosfenopril

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Fosfenopril

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

95399-71-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Fosinoprilat
Fosinoprilic acid
SQ 27519

产品介绍

Fosfenopril (Fosinoprilat) 是一种有效的血管紧张素转换酶 (ACE) 抑制剂。Fosfenopril 通过抑制单核细胞中TLR4/NF-κB信号通路缓解脂多糖 (LPS) 诱导的炎症反应。

生物活性

Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibitingTLR4/NF-κBsignaling in monocytes^[1]^[2].

IC₅₀& Target

TLR4

NF-κB

IL-6

IL-1β

体外研究
(In Vitro)

Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS^[1].
Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS^[1].
Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression^[1].

Western Blot Analysis^[1]

Cell Line:	THP1 cells
Concentration:	0, 0.25, 0.5, 1, 5, and 10 μM
Incubation Time:	1 h
Result:	Down-regulated the expression of NF-κB protein.

RT-PCR^[1]

Cell Line:	THP1 cells
Concentration:	0, 0.25, 0.5, 1, 5, and 10 μM
Incubation Time:	5 min
Result:	Showed a dose-dependent inhibitory effect on the TLR4 expression.

体内研究
(In Vivo)

Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs^[3].

Animal Model:	Famale mongrel dogs (n=7)^[3]
Dosage:	0.5 mg/kg (1.1 mumol/kg) bolus plus 0.1 mg/kg/min (0.22 mumol/kg/min)
Administration:	IV, once
Result:	Increased p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) by 25 and 16%, respectively without changing arterial pressure (AP).

分子量

435.49

Formula

C₂₃H₃₄NO₅P

CAS 号

95399-71-6

中文名称

福辛普利拉EP杂质A)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.