CAS NO: | 700-06-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
200mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
生物活性 | Indole-3-carbinol (I3C) inhibitsNF-κBactivity and also is anAryl hydrocarbon receptor(AhR) agonist, and an inhibitor ofWWP1(WW domain-containing ubiquitin E3 ligase 1). | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | It is found that Indole-3-carbinol (I3C) inhibits the proliferation of THP-1 cells in a dose- and time dependent manner with minimal toxicity over normal monocytes. The AhR target genes (CYP1A1, IL1β) are overexpressed upon Indole-3-carbinol treatment (p<0.05 to p<0.001). The antiproliferative effects of Indole-3-carbinol are in association with programing cell death. Indole-3-carbinol downregulates BCL2 and upregulates FasR in THP-1 cells (p<0.05 to p<0.001). G1 cell cycle arrest is also observed using flow cytometry. G1-acting cell cycle genes (P21, P27 and P53) are overexpressed (p<0.05 to p<0.001), while CDK2 is downregulated upon Indole-3-carbinol treatment (p<0.01 to p<0.001)[1].Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 147.17 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C9H9NO | ||||||||||||||||
CAS 号 | 700-06-1 | ||||||||||||||||
中文名称 | 3-吲哚甲醇 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(679.49 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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