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Nrf2-ARE/hMAO-B/QR2 modulator 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nrf2-ARE/hMAO-B/QR2 modulator 1图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Nrf2-ARE/hMAO-B/QR2 modulator 1 是一种基于白藜芦醇 (Resveratrol) 的多靶点定向配体,对hMAO-BNRF2QR2IC50分别为 8.05 μM、9.83 μM 和 0.57 μM。Nrf2-ARE/hMAO-B/QR2 modulator 1 具有神经保护作用,可降低冈田酸处理过的小鼠海马切片中ROS的产生。
生物活性

Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands withIC50s of 8.05, 9.83 and 0.57 μM forhMAO-B,NRF2andQR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasingROSproduction in okadaic acid-treated mice hippocampal slices[1].

IC50& Target

IC50: 8.05 μM (hMAO-B), 9.83 μM (NRF2), 0.57 μM (QR2)[1]

体外研究
(In Vitro)

Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (OA)) significantly increases the cell viability of OA-treated rat primary cortical neurons to 70-80%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (10 μM) shows the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), as well as the greatest distance of cell migration in mice NSCs which isolated from SGZ[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 72 hours) confers neuroprotection and reduces cell death, decreasing ROS production in mice hippocampal slices exposed to OA[1].

分子量

256.26

Formula

C14H12N2O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.