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AZD4694
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD4694图片
CAS NO:1054629-49-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
NAV4694
产品介绍
AZD4694 (NAV4694) 是一种氟化 β-淀粉样蛋白 (Aβ) 斑块神经成像的 PET 放射配基,对纤维具有高度亲和力 (Kd= 2.3 nM)。
生物活性

AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity forAβ fibrils(Kd= 2.3 nM)[1].

IC50& Target

Kd: 2.3 nM (Aβ)

体内研究
(In Vivo)

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].

Animal Model:Male Sprague–Dawley rats (275-300 g)[1]
Dosage:4 mL/kg
Administration:I.v.
Result:Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.
Clinical Trial
分子量

258.25

Formula

C14H11FN2O2

CAS 号

1054629-49-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.