AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity forAβ fibrils(K_d= 2.3 nM)^[1].

Kd: 2.3 nM (Aβ)

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue^[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [³H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients^[1].

258.25

C₁₄H₁₁FN₂O₂

1054629-49-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.