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N-Arachidonylglycine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Arachidonylglycine图片
CAS NO:179113-91-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
N-Arachidonylglycine (NA-Gly) 是内源性大麻素 anandamide (AEA) 的羧基类似物,是一种 GPR18 激动剂 (EC50 = 44.5 nM)。
Cas No.179113-91-8
别名N-Arachidonyl Glycine, NAGly
化学名2-((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido)acetic acid
Canonical SMILESO=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCC(O)=O
分子式C22H35NO3
分子量361.52
溶解度50mg/mL in ethanol, 10mg/mL in metyle acetate, 15mg/mL in DMSO, 20mg/mL in DMSO
储存条件Store at -80℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide),1 from extracts of mammalian brain,2,3 and has also been synthesized as an analog of AEA for structure/activity testing.4 NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments.[1],[2],[3] Since it seems to be a very poor ligand for the CB1 receptor,[4] these effects are probably mediated via other signaling pathways.

Reference:
[1]. Burstein, S.H., Rossetti, R.G., Yagen, B., et al. Oxidative metabolism of anandamide. Prostaglandins & Other Lipid Mediators 61, 29-41 (2000).
[2]. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification and characterization of an endogenous anandamide-like compound: N-arachidonylglycine (NAGly). ICRS 2001 Symposium on the Cannabinoids 78 (2001).
[3]. Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. The Journal of Biological Chemisty 276(46), 42639-42644 (2001).
[4]. Sheskin, T., Hanus, L., Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. Journal of Medicinal Chemistry 40, 659-667 (1997).