CAS NO: | 93479-97-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50of 182 μg/kg. | ||||||||||||||||
IC50& Target | DPP4[1]. | ||||||||||||||||
体内研究 (In Vivo) | Glimepiride (Glimperide) is a new sulfonylurea. After oral administration of Hoe 490 to rabbits, blood glucose was lowered 3.5 times more than after glibenclamide (HB 419) and after intravenous administration, 2.5 times more[1]. Glimepiride (Glimperide) decreased extracellular Aβ40 and Aβ42 levels. glimepiride may serve as a promising drug for the treatment of AD associated with diabetes[2]. Glimepiride (Glimperide) was generally associated with lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Glimepiride (Glimperide) use may be safer in patients with cardiovascular disease because of its lack of detrimental effects on ischemic preconditioning[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 490.62 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H34N4O5S | ||||||||||||||||
CAS 号 | 93479-97-1 | ||||||||||||||||
中文名称 | 格列美脲 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(67.93 mM;Need ultrasonic) H2O : 0.1 mg/mL(0.20 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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