hCA IX-IN-2

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hCA IX-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

hCA IX-IN-2 是一种有效的选择性hCA IX抑制剂，K_I值为 32.1 nM。hCA IX-IN-2 具有抗增殖活性。

生物活性

hCA IX-IN-2 is a potent and selectivelyhCA IXinhibitor with anK_Ivalue of 32.1 nM. hCA IX-IN-2 shows anti-proliferative activity^[1].

IC₅₀& Target

hCA IX

32.1 nM (Ki)

hCA XII

8.1 nM (Ki)

hCA VII

15.9 nM (Ki)

hCA XIII

95.7 nM (Ki)

体外研究
(In Vitro)

hCA IX-IN-2 (compound 7c) (0-100 μM; 24 h) 显示抗增殖活性，对 HDF, MeWo, LN-229, SaOS-2, HepG2 细胞的 IC₅₀值分别为 62.5, 0.7121, 12.11, 7.834, 2.356 μM^[1]。
hCA IX-IN-2 (62.5 μM for NHDF, 2.365 μM for HepG2) 显着降低 NHDF 和 HepG2 细胞中 O2^o-的产生^[1]。

Cell Cytotoxicity Assay^[1]

Cell Line:	NHDF, MeWo, LN-229, SaOS-2, HepG2 cells
Concentration:	0, 5, 10, 30, 70, 100 μM
Incubation Time:	24 h
Result:	Inhibited cell growth with IC₅₀s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively.

分子量

552.11

Formula

C₂₃H₂₄N₂O₄STe

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.