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DPP IV/hCA II-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPP IV/hCA II-IN-1图片
CAS NO:2836996-95-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂,抑制 DPP IV 的IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的Ki值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。
生物活性

DPP IV/hCA II-IN-1 is a potent and selectivedipeptidyl peptidaseIV (DPP IV)andcarbonic anhydrase(CA)inhibitor with anIC50value of 0.049 μM for DPP IV and withKivalues of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX,CA I, and CA IV, respectively[1].

IC50& Target

CA Ⅱ

36.1 nM (IC50)

CA I

0.2615 μM (Ki)

hCA II

0.0361 μM (Ki)

hCA IX

0.1328 (Ki)

体外研究
(In Vitro)

DPP IV/hCA II-IN-1 (compound 12; 100 nM and 5 μM; 1 h; Caco-2 cells) inhibits cellular DPP IV activity by 60.65% and 71.86% at 100.0 nM and 5.0 μM, respectively[1].
DPP IV/hCA II-IN-1 (1.0 μM) can be uptaken by Caco-2 cells to 2874, 4562, and 6250 RFU after 15, 30, and 60 min, respectively[1].

体内研究
(In Vivo)

DPP IV/hCA II-IN-1 (compound 12; 2 μM, 0.5 mg/mL; CD-1 mouse and Sprague-Dawley (SD) rat) exhibits modest stability in mouse and rat microsomes with 27.5 and 16.7% of remaining, respectively[1].

分子量

364.42

Formula

C17H20N2O5S

CAS 号

2836996-95-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.