DPP IV/hCA II-IN-1 is a potent and selectivedipeptidyl peptidaseIV (DPP IV)andcarbonic anhydrase(CA)inhibitor with anIC₅₀value of 0.049 μM for DPP IV and withK_ivalues of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX,CA I, and CA IV, respectively^[1].

DPP IV/hCA II-IN-1 (compound 12; 100 nM and 5 μM; 1 h; Caco-2 cells) inhibits cellular DPP IV activity by 60.65% and 71.86% at 100.0 nM and 5.0 μM, respectively^[1].
DPP IV/hCA II-IN-1 (1.0 μM) can be uptaken by Caco-2 cells to 2874, 4562, and 6250 RFU after 15, 30, and 60 min, respectively^[1].

DPP IV/hCA II-IN-1 (compound 12; 2 μM, 0.5 mg/mL; CD-1 mouse and Sprague-Dawley (SD) rat) exhibits modest stability in mouse and rat microsomes with 27.5 and 16.7% of remaining, respectively^[1].

364.42

C₁₇H₂₀N₂O₅S

2836996-95-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.