您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Sordarin(sodium salt)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Sordarin(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sordarin(sodium salt)图片
CAS NO:463356-00-5
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Sordarin 是一种有效的 diphthamide-dependent eEF2 抑制剂，具有抗真菌特性。
Cas No.463356-00-5
别名SORDARINSODIUMSALT钠盐
化学名(1R,3aR,4S,4aR,7R,7aR,8aS)-8a-[[(6-deoxy-4-O-methyl-β-D-altropyranosyl)oxy]methyl]-4-formyl-4,4a,5,6,7,7a,8,8a-octahydro-7-methyl-3-(1-methylethyl)-1,4-methano-s-indacene-3a(1H)-carboxylic acid, monosodium salt
Canonical SMILESC[C@H]1O[C@@H](OC[C@@]23[C@@](C(C(C)C)=C[C@@]3([H])C4)(C([O-])=O)[C@@]4(C=O)[C@@]5([H])[C@]([C@H](C)CC5)([H])C2)[C@@H](O)[C@H](O)[C@@H]1OC.[Na+]
分子式C27H39O8.Na
分子量514.6
溶解度Soluble in water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).

Reference:
[1]. Domínguez, J.M., Gómez-Lorenzo, M.G., and Martín, J.J. Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. J. Biol. Chem. 274(32), 22423-22427 (1999).
[2]. Domínguez, J.M., Kelly, V.A., Kinsman, O.S., et al. Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts. Antimicrob. Agents Chemother. 42(9), 2274-2278 (1998).