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Coixol(6-Methoxy-2-benzoxazolinone)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coixol(6-Methoxy-2-benzoxazolinone)图片
CAS NO:532-91-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
Coixol (6-Methoxy-2-benzoxazolinone) (6-Methoxy-2-benzoxazolinone;6-MBOA) 是从薏苡仁 (Coix lachryma-jobiL.
Cas No.532-91-2
别名6-甲氧基-2-苯唑啉酮,6-Methoxy-2-benzoxazolinone; 6-MBOA
Canonical SMILESO=C1OC2=CC(OC)=CC=C2N1
分子式C8H7NO3
分子量165.15
溶解度DMSO : ≥ 30 mg/mL (181.65 mM)
储存条件Store at 4°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37℃ in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo:

[1]. Lee HJ, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38(5):620-7. [2]. Rahman M Hafizur, et al. Coixol Exerts an Exclusive Glucose-dependent Insulinotropic Effect in βTC-6Cells. Hafizur et al., J Cytol Histol 2015, 6:3