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AZD 3988
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD 3988图片
CAS NO:892489-52-0
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
AZD 3988 是一种具有口服活性的 diacylglycerol acyl transferase-1 (DGAT-1) 抑制剂。
Cas No.892489-52-0
别名反式-4-[4-[[[5-[(3,4-二氟苯基)氨基]-1,3,4-恶二唑-2-基]羰基]氨基]苯基]环己烷乙酸
化学名5-((3,4-difluorophenyl)amino)-N-(4-((1r,4r)-4-methylcyclohexyl)phenyl)-1,3,4-oxadiazole-2-carboxamide compound with methanedione (1:1)
Canonical SMILESO=C(C1=NN=C(NC2=CC(F)=C(F)C=C2)O1)NC(C=C3)=CC=C3[C@@H]4CC[C@@H](C[H])CC4.O=C=O
分子式C23H22F2N4O4
分子量456.44
溶解度<45.64mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1].

References:
[1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.