(-)-Securinine is plant-derived alkaloid and also aGABA_Areceptorantagonist.

GABA_Areceptor^[1]

(-)-Securinine is a major plant-derived alkaloid and also a GABA_Areceptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC₅₀values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine^[1].

In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period^[2].

217.26

Solid

C₁₃H₁₅NO₂

5610-40-2

一叶秋碱

• Alkaloids
• Pyridine Alkaloids

• Plants
• Euphorbiaceae
• Flueggea suffruticosa(Pall.) Baill.

Room temperature in continental US; may vary elsewhere.

DMSO : 2 mg/mL(9.21 mM;Need ultrasonic)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。