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Ivacaftor benzenesulfonate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ivacaftor benzenesulfonate图片
CAS NO:1134822-09-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
VX-770 benzenesulfonate
产品介绍
Ivacaftor benzenesulfonate (VX-770 benzenesulfonate) 是一种可口服的CFTR增强剂,可用于囊性纤维化的研究。
生物活性

Ivacaftor benzenesulfonate is an orally bioavailableCFTRpotentiator, used for cystic fibrosis treatment.

体外研究
(In Vitro)

Ivacaftor (10 μM) increases the PC secretion activity by 3-fold for ABCB4-G535D, 13.7-fold for ABCB4-G536R, 6.7-fold for ABCB4-S1076C, 9.4-fold for ABCB4-S1176L, and 5.7-fold for ABCB4-G1178S. Ivacaftor corrects the functional defect of ABCB4 mutants[1]. Ivacaftor (10 μM) significantly increases CFTR activity in W1282X-expressing cells compared to R1162X CFTR cells[2]. Ivacaftor shows no significant activity against 160 targets tested including the GABAAbenzodiazepine receptor. Ivacaftor increases the chloride secretion with an EC50of 0.236 ± 0.200 μM, a 10-fold shift in potency compared to the F508del HBEs[3]. In recombinant cells, VX-770 increases CFTR channel open probability (Po) in both the F508del processing mutation and the G551D gating mutation. VX-770 increases forskolin-stimulated ITin temperature-corrected F508del-FRT cells by appr 6-fold with an EC50of 25 nM[4].

体内研究
(In Vivo)

Ivacaftor (1-200 mg/kg, p.o.) exhibits good oral bioavailability in rat[3].

Clinical Trial
分子量

550.67

Formula

C30H34N2O6S

CAS 号

1134822-09-5

中文名称

依伐卡托苯磺酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.