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L-Ascorbic acid 2-phosphate magnesium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Ascorbic acid 2-phosphate magnesium图片
CAS NO:113170-55-1
包装与价格:
包装价格(元)
100mg电议
500mg电议
1 g电议
5 g电议

产品名称
维生素C磷酸酯镁
2-Phospho-L-ascorbic acid magnesium
产品介绍
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是一种长效的维生素 C 衍生物 (vitamin C derivative),可以刺激胶原蛋白的表达和形成。L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 可以作为培养基补充人脂肪干细胞 (hASCs) 的成骨分化。L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 增加成骨细胞分化过程中 hASC 中的碱性磷酸酶 (ALP) 活性和 runx2A 的表达。
生物活性

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulatecollagen formationand expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for theosteogenic differentiationof human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increasesalkaline phosphatase(ALP)activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 μM-250 μM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex[3].

Cell Viability Assay[1]

Cell Line:Human corneal endothelial cells (HCECs)
Concentration:0.1 mM; 0.3 mM; 1.5 mM
Incubation Time:2 to 3 weeks with medium exchange every 2 to 3 days
Result:Stimulated HCEC cells growth.
分子量

292.56

性状

Solid

Formula

C6H9O9P.3/2Mg

CAS 号

113170-55-1

中文名称

L-抗坏血酸2-磷酸酯;维生素C磷酸酯镁

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)