| CAS NO: | 2738-64-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶（复合物 I）抑制剂。
| Cas No. | 2738-64-9 |
| 别名 | 粉蝶霉素A,AR 054, Shaoguanmycin B, SN 198E |
| 化学名 | 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol |
| Canonical SMILES | COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C)=C/C)C)N=C1OC |
| 分子式 | C25H37NO4 |
| 分子量 | 415.6 |
| 溶解度 | Soluble in DMSO, Soluble in DMF, Soluble in Ethanol, Soluble in Methanol |
| 储存条件 | Store at -80℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Piericidin A is a mitochondrial complex I inhibitor. Complex I, also known as NADH:ubiquinone oxidoreductase, catalyzes the transfer of electrons from NADH to ubiquinone as part of the respiratory chain resulting in ATP generation. In vitro: Previous study found that piericidin A could inhibit the electron transport system at two sites. Piericidin A specifically reacted at very low concentrations at a site near the reduced NADH dehydrogenase. At high concentrations, piericidin A inhibited the succinic dehydrogenase system, and the inhibition could be partially reversed by coenzyme Q. Moreover, it was found that both the succinate and NADH oxidase system were inhibited at high levels of piericidin A [1]. In vivo: Animal study was performed to evaluate the effect of piericidin A and antagonistic effect of vitamin K3 on respiration, blood pressure and heart rate in rats. Results showed that 0.167 mg/kg of piericidin A increased the respiratory rate and the lowered blood pressure rapidly. Furthermore, vitamin K3 (10-40 mg/kg) could restore the responses to piericidin A in rats [2]. Clinical trial: Up to now, piericidin A is still in the preclinical development stage. References: |
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