Hyperforin

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Hyperforin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

11079-53-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Hyperforin 是瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin 通过激活 Ca²⁺传导非选择性典型 TRPC6 通道来调节 Ca²⁺水平。Hyperforin 还表现出多种药理活性，包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。Hyperforin 调节 γδ T 细胞分泌 IL-17α，改善 Imiquimod (HY-B0180) 诱导的银屑病样小鼠皮肤炎症。

生物活性

Hyperforin is atransient receptor canonical 6 (TRPC6)channels activator. Hyperforin modulates Ca²⁺levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improvesImiquimod(HY-B0180)-induced psoriasis-like mice model^[1]^[2]^[3]^[4]^[5].

IC₅₀& Target

TRPC6^[1]

体外研究
(In Vitro)

Hyperforin 具有多向作用机制。它阻断配体门控 (GABA、NMDA 和 AMPA 受体) 和电压门控通道(Ca²⁺， K⁺， Na⁺) 的电导^[2]。
Hyperforin (0.1, 1,10 μM; 2 h) 降低体外培养的小鼠脾 γδ T 细胞中 IL-17A 的表达和分泌^[3]。
Hyperforin (0.1, 1,10 μM; 2 h) 抑制 TNF-α 刺激的 HaCaT 细胞中 MAPK 和 STAT3 通路的磷酸化^[3]。
Hyperforin (IC₅₀=3.7 μmol/L) 抑制 HDMEC 微血管管的形成和增殖，呈剂量依赖性，无毒性作用^[4]。

Western Blot Analysis^[3]

Cell Line:	HaCaT cells
Concentration:	0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α
Incubation Time:	2 hours
Result:	Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.

体内研究
(In Vivo)

Hyperforin (5 mg/kg; 腹腔注射; 每天 1 次, 共 7 天) 能够改善Imiquimod(HY-B0180) 诱导的小鼠银屑病皮损情况，抑制炎症细胞浸润和炎症因子释放^[3]。

Animal Model:	IMQ-induced psoriasis-like mice model^[3]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; once daily for 7 days
Result:	Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation. Suppressed infiltration of CD3+ T cells and downregulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.

分子量

536.78

Formula

C₃₅H₅₂O₄

CAS 号

11079-53-1

结构分类

Antibiotics

来源

Plants
Guttiferae
Hyperlcurn perforatumL.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.