Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger forcalcium mobilizationthat is synthesized from NAD⁺by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly byRyanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening ofTRPM2 channels^[1][2][3].

Calcium mobilization^[1]
TRPM2 channels^[3]
Endogenous metabolite^[1]

cADPR (20 nM) elicits a large rapid Ca²⁺release in sea urchin eggs homogenates^[1].
cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes^[4].
cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture^[5].

cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice^[5].

Solid

C₁₅H₂₁N₅O₁₃P₂.xNH₃

• Others

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)