您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Raf inhibitor 1 dihydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Raf inhibitor 1 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Raf inhibitor 1 dihydrochloride图片
CAS NO:1191385-19-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
B-Raf inhibitor 1 dihydrochloride 是一种有效的Raf激酶抑制剂,作用于 B-RafWT, B-RafV600E, 和 C-Raf,Ki分别为 1 nM, 1 nM, 和 0.3 nM。
生物活性

B-Raf inhibitor 1 dihydrochloride is a potentRafkinase inhibitor withKis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, andC-Raf, respectively.

IC50& Target[1]

B-Raf

1 nM (Ki)

B-RafV600E

1 nM (Ki)

c-Raf

0.3 nM (Ki)

体外研究
(In Vitro)

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers[1].

分子量

551.86

Formula

C26H21Cl3N8

CAS 号

1191385-19-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.