CAS NO: | 1191385-19-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | B-Raf inhibitor 1 dihydrochloride is a potentRafkinase inhibitor withKis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, andC-Raf, respectively. | |||
IC50& Target[1] |
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体外研究 (In Vitro) | B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers[1]. | |||
分子量 | 551.86 | |||
Formula | C26H21Cl3N8 | |||
CAS 号 | 1191385-19-9 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |