R18

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R18

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

211364-78-2

包装与价格：

产品名称

PHCVPRDLSWLDLEANMCLP

产品介绍

R18 是14-3-3的肽拮抗剂，其 K_D值为 70-90 nM。R18 可有效阻断 14-3-3 与其配体 Raf-1激酶的结合，可有效地消除 14-3-3 对磷酸酶诱导的 Raf-1 失活的保护作用。

生物活性	R18 is a peptide antagonists of14-3-3, with a K_Dof 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinaseRaf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation ofRaf-1^[1].
分子量	2309.69
Formula	C₁₀₁H₁₅₇N₂₇O₂₉S₃
CAS 号	211364-78-2
Sequence	Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening	PHCVPRDLSWLDLEANMCLP
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.