Belvarafenib TFA (HM95573 TFA) is a potent and panRAF(Rapidly Accelerated Fibrosarcoma) inhibitor, withIC₅₀sof 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv^600EandC-RAFrespectively^[1].

IC50: 56 nM(B-RAF), 7 nM(B-RAFv^600E), 5 nM(C-RAF)^[1].

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC₅₀values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv^600Eand C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC₅₀s of 10 nM, 23 nM and 44 nM, respectively^[1].

592.95

Solid

C₂₅H₁₇ClF₄N₆O₃S

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)