CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally availableBCR-ABL,SRCandp38kinase inhibitor withIC₅₀values of 70, 90 and 62 nM againstABL1,SRCand p38, respectively^[1].

CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI₅₀of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively^[1].

CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model^[1].

549.55

C₂₈H₂₆F₃N₇O₂

1808287-83-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.