APS-2-79 hydrochloride is aKSR-dependentMEKantagonist. APS-2-79 inhibits ATP^biotinbinding to KSR2 within the KSR2-MEK1 complexe with anIC₅₀of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling^[1].

APS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells^[1].
APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutations^[1]

423.89

C₂₃H₂₂ClN₃O₃

2002381-31-7

Room temperature in continental US; may vary elsewhere.

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