ZYF0033 (HPK1-IN-22, compound ZYF0033) is ahematopoietic progenitor kinase 1 (HPK1)inhibitor with anIC₅₀less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 decreases the phosphorylation of SLP76 (serine 376). ZYF0033 promotes anticancer immune responses. ZYF0033 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a₊CD8₊T cells but decreased infiltration of regulatory T cells,PD-1₊CD8₊T cells, TIM-3₊CD8₊T cells, and LAG3₊CD8₊T cells in the 4T-1 syngeneic mouse model^[1].

462.61

C₂₆H₃₀N₄O₂S

2380300-79-6

Room temperature in continental US; may vary elsewhere.

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