JNK3 inhibitor-3

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JNK3 inhibitor-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JNK3 inhibitor-3 (compound 15g) 是选择性的、可穿透血脑屏障、口服有效的的 c-Jun N-terminal kinase 3 (JNK3) 抑制剂。JNK3 inhibitor-3 抑制 JNK1，JNK2 和 JNK3 的IC₅₀值分别为 147.8，44.0 和 4.1 nM。JNK3 inhibitor-3 显著改善小鼠痴呆模型的记忆功能。JNK3 inhibitor-3 可用于阿尔茨海默病的研究。

生物活性

JNK3inhibitor-3 (compound 15g) is a selective, BBB permeable and orally activec-Jun N-terminal kinase3 (JNK3) inhibitor.JNK3inhibitor-3 has inhibitory activities toJNK1,JNK2andJNK3withIC₅₀values of 147.8, 44.0 and 4.1 nM, respectively.JNK3inhibitor-3 significantly improves the memory in mouse dementia model.JNK3inhibitor-3 can be used for the research of Alzheimer’s disease^[1].

IC₅₀& Target

JNK3

4.1 nM (IC₅₀)

JNK2

44 nM (IC₅₀)

JNK1

147.8 nM (IC₅₀)

体外研究
(In Vitro)

JNK3 inhibitor-3 (0-10 μM) 对 JNK1，JNK2 和 JNK3 具有抑制活性，IC₅₀值分别为 147.8，44.0 和 4.1 nM^[1]。
JNK3 inhibitor-3 (20 μM; 24-48 h) 表现出体外神经保护作用^[1]。

Cell Viability Assay^[1]

Cell Line:	Rat cortical neurons
Concentration:	20 μM
Incubation Time:	24 and 48 hours
Result:	Protected rat cortical neurons against 10 μM Aβ_1-42induced neurotoxicity.

体内研究
(In Vivo)

JNK3 inhibitor-3 (30 和 60 mg/kg；口服，每天 1 次，连续 2 或 2.2 个月) 改善 3xTg 小鼠痴呆模型的记忆^[1]。

Animal Model:	Homozygous 3xTg and APPswe/PS1dE9 double-transgenic mice model of Alzheimer’s disease^[1]
Dosage:	30 and 60 mg/kg
Administration:	Oral administration; once daily for 2 or 2.2 month
Result:	Induced no abnormal symptoms or weight changes, significantly enhanced the spontaneous alteration in APP/PS1 and doses of 30 and 60 mg/kg than that of vehicle group in Y-maze test and showed a significant difference compared to the 3xTg vehicle control in the passive avoidance test.

分子量

467.52

Formula

C₂₆H₂₅N₇O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.