ERK-IN-2 free base is aERK2inhibitor with anIC₅₀value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM^[1].

ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC₅₀of 280 nM^[1].
ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC₅₀values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively^[1].

ERK-IN-2 (1 mpk, p.o.; or 0.5 mpk, i.v.; rat) shows a t_1/2of 0.4 h, and F% of 13%^[1].

311.34

C₁₆H₁₇N₅O₂

2743576-55-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.