Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is aanti-inflammatoryagent. Anti-inflammatory agent 31 inhibitsNF-κBactivation by upstream blockade ofPI3K/AktandERK1/2 MAPKactivation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver^[1].

Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner^[1].
Anti-inflammatory agent 31 reacts as a quick rate (K_GSH=0.076 M^-1.h^-1) and long half-live (T_1/2=6.47 h)^[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels^[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC₅₀of 14.68, 26.25 μM, respectively^[1].

Anti-inflammatory agent 31 (enone 17) (i.p.; 0.3, 1.0 mg/kg) decreases total white blood cell and neutrophils counts, and alleviates LPS-induced acute lung injury in a dose-dependent manner in mouse^[1].

306.44

C₁₉H₃₀O₃

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