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STAT3-IN-9
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STAT3-IN-9图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
STAT3-IN-9 是一种有效的STAT3抑制剂。STAT3-IN-9 抑制 STAT3 (Tyr705) 的激活，而不影响 STAT1 (Tyr701) 的磷酸化。STAT3-IN-9 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。
生物活性

STAT3-IN-9 is a potentSTAT3inhibitor. STAT3-IN-9 inhibits the activation ofSTAT3(Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 inducesapoptosisand cell cycle arrest at the G2/M phase[1].

IC50& Target

STAT3

 

体外研究
(In Vitro)

STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 μM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)[1].
STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway[1].
STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner[1].

Cell Proliferation Assay[1]

Cell Line:MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells
Concentration:
Incubation Time:48 h
Result:Showed potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.

Western Blot Analysis[1]

Cell Line:MDA-MB-468 cells
Concentration:0, 0.2, 1.0, 5.0 μM
Incubation Time:24 h
Result:Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).

Apoptosis Analysis[1]

Cell Line:MDA-MB-468 cells
Concentration:0, 0.2, 1 μM
Incubation Time:24 h
Result:Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway.

Cell Cycle Analysis[1]

Cell Line:MDA-MB-468 cells
Concentration:0, 0.2, 1 μM
Incubation Time:24 h
Result:Cells were arrest at the G2/M phase in a dose-dependent manner.
分子量

391.42

Formula

C22H21N3O4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.