Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation ofSTAT3by binding selectively to Janus kinase 2 and theSTAT3Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects^[1][2].

Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells^[1].
Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines^[1].

424.49

Solid

C₂₅H₂₈O₆

52328-97-9

四甲基姜黄素

• Phenols

• Plants
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Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DMSO : 100 mg/mL(235.58 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。