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Colivelin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:867021-83-8
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Colivelin 是一种具有大脑通透性的神经保护肽 (neuroprotective peptide)，是STAT3的有效激活剂。Coliveli 通过激活 STAT3 在体外抑制神经元死亡。Colivelin 对神经毒性、Aβ 沉积,神经元细胞凋亡,在神经退行性疾病显示出长期有利的影响。Colivelin 具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。
生物活性

Colivelin is a brain penetrantneuroprotective peptideand a potent activator ofSTAT3, suppresses neuronal death by activating STAT3 in vitro[1]. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronalapoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury[1]

IC50& Target

STAT3

 

Amyloid-β

 

体外研究
(In Vitro)

Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm[1].
Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN[1].
Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition[4].
Colivelin (50 μg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells[4].

Western Blot Analysis[4]

Cell Line:BV-2 cells.
Concentration:50 μg/mL.
Incubation Time:4 hours.
Result:Increased p-STAT3 levels.

Cell Viability Assay[5]

Cell Line:KYSE70 and TE8 cells.
Concentration:0.5 μM.
Incubation Time:1 hour (followed by CYT-Rx20 treatment)
Result:Sgnificantly suppressed the viability in KYSE70 and TE8 cells.
体内研究
(In Vivo)

Colivelin (intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[1].
Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21 mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit[1].
Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO[3].

Animal Model:CD-1 mice[1]
Dosage:10 pmol/3 μl
Administration:Intracerebroventricular administration
Result:Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
Animal Model:C57 mice[1]
Dosage:1.4, 7, or 35 nM/0.21mL
Administration:Intraperitoneal administration
Result:Protected against cholinotoxin-induced amnesia in mice.
Animal Model:Male C57BL/6 mice[3]
Dosage:1 mg/kg
Administration:Intraperitoneal administration
Result:Protected against ischemic brain injury, and improves neurological outcomes
分子量

2645.10

Formula

C119H206N32O35

CAS 号

867021-83-8

Sequence Shortening

SALLRSIPAPAGASRLLLLTGEIDLP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.