| CAS NO: | 440-17-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 480.42 |
|---|---|
| Formula | C21H24F3N3S.2HCl |
| CAS No. | 440-17-5 (dihydrochloride salt); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 88 mg/mL (183.2 mM) |
| Water: 96 mg/mL (199.8 mM) | |
| Ethanol: 96 mg/mL (199.8 mM) | |
| SMILES | FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl |
| Synonyms | SKF5019; SKF 5019; SKF-5019; Trifluoperazine hydrochloride; NSC 17474; NSC-17474; NSC17474; Trifluoperazine HCl; Tryptazine dihydrochloride; Trazine; |
| In Vitro | In vitro activity: Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). |
|---|---|
| In Vivo | Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. |
| Animal model | Rats |
| Formulation & Dosage | N/A |
| References | Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4; J Pharmacol Exp Ther. 1999 Aug;290(2):901-7. |
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